The adenomatous colloid nodules are either observed or suppressed by thyroxin, also surgery is recommended if the nodule grows; for the exclusion of malignancy. This finding suggests that in presence of micro calcification, the incidence of malignancy is more. DNA aneuploidy was found to be more common in males, old age, extrathyroid extension, poor histological differentiation and metastasis. Risk of malignancy in nonpalpable thyroid nodules: Final HPE showed malignancy in 20 Indian J Endocrinol Metab. Percutanous ethanol injection under sonographic guided is a relatively safe, low cost, outpatient method of treatment that has been applied successfully as an alternative to surgery for the management of benign and malignant lesions of various tissues and organs.

This high incidence of malignancy reported in our study is similar to that of Tai et al. We have noted that male gender, micro calcification, solid echogenicity of the nodule, and presence of cervical lymphadenopathy was significantly associated with malignancy as noted by Tai et al. Pathology of thyroid nodule. The present study was based on the review of case records of all patients who were operated for STN. Abstract The solitary thyroid nodule is a common problem in clinical practice. NY State J Med.

solitary thyroid nodule thesis

The management ondule thyroid nodules requires a combination of clinical evaluation followed by appropriate investigations. Also provides fantastic magnification of thyroid anatomy, including the recurrent laryngeal nerve, superior laryngeal nerve, and the parathyroid glands.

Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation

Three patients with medullary carcinoma were kept on close follow-up. The sensitivity of thyroid FNAC in detection of neoplastic lesions was The only value of the other methods of diagnosis became in supportive role.

Only 14 pages are availabe for public view. Predictive value of ultrasound and color-Doppler features. Patients with aneuploid differentiated thyroid tumors have poorer prognosis compared with patients with diploid tumors.


The aim of the present study was to evaluate patients thyroif clinically detected STN for the presence of malignancy, in relation to various factors like age, gender, thyroidd ultrasonography USG findings like size of the nodule, echogenicity, micro calcification, and presence of lymphadenopathy.

solitary thyroid nodule thesis

FNA should also be performed on nodules with suspicious ultrasonographic features microcalcifications, rounded shape, predominantly solid composition ; dominant or atypical nodules in multinodular goiter; complex or recurrent cystic nodules; or any nodule associated with palpable or ultrasonographically abnormal cervical lymph nodes. The operative procedure was based on the different parameters like age of the patients, clinical examination, fine-needle aspiration cytology FNAC findings, USG interpretation, and indirect laryngoscopy.

Anti-Gal3 antibody immunoreactivity was observed in 2 out of these 12 cases All the patients who presented to the outpatient department with a clinically detected STN were included in the study group.

Hemithyroidectomy was done in 56 Can we avoid repeat biopsy? Hypocalcemic features were managed with supplementation of calcium and Vitamin D.

Malignancy in solitary thyroid nodule: A clinicoradiopathological evaluation

C is the most important investigation that can distinguish benign from malignant lesions; however it has also some drawbacks such as false negative results and can not differentiate between follicular adenoma and carcinoma. At present, FNAC has replaced other methods, and becomes the first and the routine method which must be used thesiis diagnosis of solitary thyroid nodules. Soljtary cases were diagnosed as suspicious for papillary carcinoma by FNAC, two of them were papillary carcinoma and the other two were non-neoplastic adenomatous goiter in histopathological examination.

Objective of the study was to study the clinco-pathological correlation of solitary thyroid nodule and the incidence of malignancy. Final HPE showed malignancy in 20 The morbidity and mortality rates of thyroid cancer are low compared with the rates for many other cancers A thyroid nodule is a discrete lesion within the thyroid gland that is sonographically distinguishable from the adjacent parenchyma.


Thyroix some cases decision of solitady node dissection was taken intra operatively mainly for central nodes level VI. Only 14 pages are availabe for public view. Contemporary Management of Solitary Thyroid Nodule.

Author: Mohamed ,Mohamed Mamdouh,/ Title: Radiological management of solitary thyroid Nodule/

Clinical examination including determination of presence or absence of toxic manifestations and enlarged cervical lymph nodes was done. Thyroid nodule size and prediction of cancer. Hemostasis, safeguarding of the recurrent laryngeal nerve, parathyroid, and other vital thtroid was taken care of during the dissection. High prevalence of undetected thyroid disorders in an iodine sufficient adult south Indian population. Anti-Gal3 antibody immunoreactivity was observed in 7 out of 8 cases Histopathology findings Histopathology was nodular goiter in 77 Each patient was subjected to fine needle aspiration cytology FNAC examination, and cell block preparation.

For all cases, histopathological examination of the corresponding surgical samples, and immunohistochemical analysis of cell block specimens to detect antibody reactivity against Cytokeratin, HBME-1, and Galectin-3 were also performed. One hundred and thirty eight They should thyroi characterized properly for optimum management.

However, surgery may be indicated in patients with a benign STN with high risk for malignancy.

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